Role of astrocytic mitochondria in ischemic stroke

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the Key Research and Development Program of Hebei Province[No. 20370509D]; the Natural Science Foundation of Hebei Province(H2020208032);the Science and Technology Project of Hebei Education Department[No. ZD2020117]; the Science and Technology Program of Hebei Administration of Traditional Chinese Medicine[No. 2020268]; the

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    Ischemic stroke is a common acute cerebrovascular disease in middle-aged and old people. It is the most dangerous diseases in the world today. Astrocytes are emerging into the limelight as central components of CNS functioning and astrocytic mitochondria is essential in promoting neural survival and neurological improvement following ischemic stroke. This review will first describe what happens in terms of bioenergetic changes and intracellular mitochondrial dynamics within astrocytes and their mitochondria during ischemia. Subsequently, we will move to the transfer of functional mitochondria from astrocytes to neurons. Lastly, The regulation of astrocytic mitochondria on cerebral blood flow was reviewed. Thus targeting astrocytic mitochondria may be a novel approach to improve clinical treatment effect.

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  • Received:April 13,2021
  • Revised:May 21,2021
  • Adopted:June 30,2021
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