纳米载药体系在肿瘤耐药治疗中的应用研究进展
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国家自然科学基金(81760750); 河北省自然科学基金(H2020208018,C2020208023)


Research progress in the application of nano drug delivery system in the treatment of tumor drug resistance
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    摘要:

    肿瘤是目前引起人类死亡的棘手疾病之一,虽然通过各种现代化治疗手段使肿瘤患者的预后得到了一定程度的改善,但多药耐药依然是导致肿瘤治疗效果不佳的主要难题。纳米材料是近年来的研究热点之一,具有EPR(enhanced permeability and retention)效应、可控修饰、靶向性等众多优点,在突破肿瘤耐药方面得到了愈来愈多的关注。纳米载药体系在肿瘤治疗中发挥着极其重要的作用,可以成为逆转肿瘤耐药的新方式。从肿瘤多药耐药机制、纳米技术在肿瘤耐药中的应用等方面进行综述。指出今后可在以下方面展开深入研究:1)结合肿瘤耐药机制研究,合理控制药物浓度,克服耐药;2)深入探索纳米载药体系的生物安全问题,优化纳米载药系统,使其避免或降低可能出现的毒副反应,为逆转肿瘤耐药提供更全面的理论依据;3)结合免疫学、光动力学、声动力学等多种方法,提高纳米载药体系逆转肿瘤耐药的效率。

    Abstract:

    Tumor is one of the intractable diseases causing human death at present.Although the prognosis of tumor patients has been improved to a certain extent through various modern treatment methods,multidrug resistance is still the main problem leading to poor tumor treatment effect.Nanomaterials are one of the research hotspots in recent years.They have many advantages,such as EPR(enhanced permeability and retention) effects,controllable modification and targeting,and have attracted more and more attention in the breakthrough of tumor drug resistance.Nano drug delivery system plays an important role in tumor therapy and can be a new way to reverse tumor drug resistance.The mechanism of multidrug resistance and the application of nanotechnology in drug resistance were reviewed.It is pointed out that further research should be carried out in the following aspects: 1) Combining with the mechanism of tumor drug resistance,reasonably control drug concentration to overcome drug resistance;2) Further explore the biosafety of nanodrug delivery system,optimize the nanodrug delivery system,avoid or reduce possible toxic and side reactions,and provide a more comprehensive theoretical basis for reversing tumor drug resistance;3) Improve the efficiency of reversing tumor drug resistance of nanodrug delivery system by combining immunology,photo dynamics,acoustic dynamics and other methods.

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张新雨,冯亚婵,张皓杰,杜 朝,郭学玲,王英泽.纳米载药体系在肿瘤耐药治疗中的应用研究进展[J].河北科技大学学报,2022,42(4):417-425

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  • 收稿日期:2022-03-22
  • 最后修改日期:2022-05-23
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  • 在线发布日期: 2022-09-09
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