喹诺酮类抗生素对两种水生生物氧化应激系统的影响研究
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河北省环保厅公益课题; 河北省药用分子化学实验室开放基金


Study of the effects of quinolone antibiotics on two aquatic
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    摘要:

    为探究水生生物受喹诺酮类抗生素影响的作用机制,选取2种典型的喹诺酮类抗生素——氧氟沙星和诺氟沙星,将斜生栅藻和斑马鱼分别置于其溶液中暴露,在第5,10,15 d,检测并比较氧氟沙星和诺氟沙星质量浓度为0,30,60,120,360 mg/L时对斑马鱼和斜生栅藻体内SOD和CAT氧化应激指标的影响。结果表明:喹诺酮类抗生素对斑马鱼和斜生栅藻SOD活性的影响趋势相似,说明斑马鱼和斜生栅藻SOD活性受影响的程度基本相同;喹诺酮类抗生素对斑马鱼和斜生栅藻CAT活性的影响呈现不同趋势,说明不同水生生物维持体内细胞抗氧化环境平衡的能力不同;喹诺酮类抗生素对斑马鱼试验组SOD活性、CAT活性影响的最大值及最小值均高于斜生栅藻试验组,说明2种喹诺酮抗生素对斑马鱼和斜生栅藻SOD活性和CAT抗氧化应激反应强度的影响存在明显差异。研究结果为进一步研究喹诺酮类抗生素对水生生物的生态毒性效应提供了科学根据。

    Abstract:

    In order to explore the action mechanism of aquatic organisms affected by quinolones, two typical quinolone antibiotics, ofloxacin and norfloxacin, were selectedto expose scenedesmus obliquus and zebrafish in their solutions. After 5, 10 and 15 days, the effects of ofloxacin and norfloxacin at the mass concentrations of 0, 30, 60, 120, 360 mg/L on SOD and CAT oxidative stress indexes in zebrafish and scenedesmus obliquus were detected and compared, respectively. The results show that quinolone antibiotics have a similar effect on the SOD activity of zebrafish and scenedesmus obliquus, which indicates that the effects on SOD activity of zebrafish and scenedesmus obliquus are basically the same.The effects of quinolones on CAT activity of zebrafish and Scenedesmus obliquus present different trends, which indicates that different aquatic organisms have different abilities to maintain the balance of cellular antioxidant environments. The maximum and minimum values of SOD and CAT activities influenced by quinolone antibiotics in zebrafish test group are both higher than those of in scenedesmus obliquus test group, which shows there are significiant differences in SOD activity and CAT antioxidant stress response intensity between zebrafish and Scenedesmus obliquus. The results provide a scientific basis for further research on the ecological toxicity effect of quinolones on aquatic organisms.

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郑栋赫,杨 雷,沈洪艳.喹诺酮类抗生素对两种水生生物氧化应激系统的影响研究[J].河北科技大学学报,2020,41(4):374-380

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  • 收稿日期:2020-06-18
  • 最后修改日期:2020-07-20
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  • 在线发布日期: 2020-08-29
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