Aiming at the currently problem that data dissemination protocols in opportunistic networks are mainly based on single-source and multi-destination model, a multi-source and multi-destination data dissemination model for opportunistic networks is proposed, and an interest-and coding-aware (ICA) data dissemination protocol is designed.First, relays encode the different data flows which satisfy the same interest via inter-flow random linear network coding and then forward them. Second, nodes sharing the same interest exchange their interest coding data with each other. Once receiving enough independent coding packets which satisfy the same interest, the nodes decode the coding packets and obtain the original interest data. At last, ONE simulation is conducted for the multi-source and multi-destination data dissemination. The result shows that compared with the data dissemination protocol based on ER, ICA can obtain lower delay while consuming fewer buffers, less network bandwidth and network cost. The research result provides a feasible and efficient solution for opportunistic networks data dissemination mechanism.