In order to measure the velocity profile of arterial and venous blood flow of human body and predict major cardiovascular diseases, the multi-electrode electromagnetic flow meter based on region weight function theory is proposed in this paper. The region weight function theory has been derived from traditional Shercliff theory and COMSOL model has been established to simulate the human limb according to the layout and relative position of skin, fat, bone, muscle, artery and vein. The cross section has been divided in to several regions and the induced voltages at different positions along the skin surface have been obtained by the electrode array. The local mean axial velocity profile of the vessel cross section is calculated, and the velocity information of the reverse flow in the arteries and veins is reconstructed. The results of three-dimensional finite element model simulation demonstrate that multi-electrode electromagnetic flow meter based on region weight function is feasible to characterize the velocity profile of arteries and veins with high accuracy. Region weight function based multi-electrode electromagnetic measurement method has some reference value for vessel blood flow velocity measurement and hemorheology anomaly monitoring of human body.