In order to improve the stability of Cur-LCL and extend the circulation time of the drug in the body, the existing methods of preparing curcumin liposomes (Cur-Lips) and curcumin long-circulating liposomes (Cur-LCL) are optimized. Cur-Lips are prepared by ethanol injection method, and the Cur-LCL is prepared by inserting DSPE-PEG2000 into Cur-Lips by post-insertion. The results show the appearance is a circular vesicular sphere, and the average encapsulation efficiency is (88.91±0.94)%, which stays unchanged at 4 ℃ for 15 days; the average leakage rate is 2.4%, which has good stability; the average particle size is (118.4±3.2) nm (n=3), showing a single peak distribution, and the average potential is (-12.9±0.32) mV (n=3); the dissolution medium is selected according to the solubility standard, and the physiological solution of 1% Tween 80 is selected as the dissolution medium for the in vitro release experiment. Cur APIs are almost completely released at 12 h while Cur-Lips are almost completely released at 36 h, and the cumulative release rate is 92.67%. Cur-LCL is almost completely released at 72 h, and the cumulative release rate is 91.36%. Cur-LCL has obvious function in slowing the release process, which could prolong the circulation time of the drug in the blood and achieve long-circulation effects.