In order to find an alternative reduction method, making the 2 -［3-chloro-5 - (trifluoromethyl) pyridine - 2- yl］ acetonitrile to be reduced to 2-［3-chlor-5 - (trifluoromethyl) pyridini-2- yl］ ethane under mild conditions，the key intermediate 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)ethan-1-amine hydrochloride is obtained through condensation of the starting material 2,3-dichloro-5-(trifluoromethyl) pyridine with ethyl-2-cyanoacetate, decarboxylation, reduction, and deprotection reaction; then the targeted compound fluopyram is synthesized through the reaction of 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)ethan-1-amine hydrochloride with 2-(trifluoromethyl)benzoyl chloride. The reaction factors and parameters are optimized. The optimized conditions are as follows: in reduction reaction, n(substrate)∶n(NiCl₂)∶n(NaBH₄)=1∶1∶2; in deprotection reaction, the deprotection reagent is hydrogen chloride in ethyl acetate solution; in amidation reaction, the reaction solvent is dichloromethane, the proton scavenger is triethylamine and the reaction temperature is 10~15 ℃. Under the optimized conditions, the total yield of fluopyram reaches 48.1% (counted based on 2,3-dichloro-5-(trifluoromethyl)pyridine). The structure of fluopyram is confirmed by ESI-MS, ¹H-NMR and ¹³C-NMR. This synthetic method is mild in response, simple in operation and has high yield of target products.