In order to solve the problem of having excessive organics, total phosphorus(TP) and other pollutants in secondary effluent from municipal wastewater treatment plant, Fenton oxidation-coagulation unit is adopted to treat the wastewater. The treatment efficiency of the treatment process is discussed through the orthogonal experiments and the single factor experiments. It shows that the removal efficiency of COD, colority and TP are 97.5%, 96.7% and 99.2% respectively under the optimal reaction conditions that the Fenton oxidation reaction time is 40 min, initial pH value is 6.0, the dosage of FeSO₄·7H₂O and H₂O₂ are 600 mg/L and 850 mg/L respectively，the coagulation reacting pH value is 8.0 and the dosage of APAM is 3.0 mg/L. The water quality can meet the first A level discharge standard of the Discharge Standard of Pollutants for Municipal Wastewater Treatment Plant (GB 18918—2002).The process, as the advanced treatment technology of wastewater, can be widely used in the advanced treatment of refractory pollutants in the municipal wastewater treatment plant.