Plate heat exchanger has unique advantages and becomes dominant heat exchange equipment in heating engineering, but there is no heating regulation formula of plate exchanger applied in central heating regulation of indirect connection hot water heating. This paper analyzes the condition that the heating user's system adopts quality regulation method and the hot water network system adopts quality-flow regulation method, and obtains the regulation formulas of plate exchanger applied in central heating regulation of indirect connection hot water heating used for the above two systems. Empirical calculation shows that the formula can be applied to the quality regulation and the mass flow regulation of the different flow optimization adjustment coefficient, and it is an all-round formula.