In order to improve the dissolution of azithromycin, azithromycin nanocrystals tablets are studied based on the nanocrystal technology. The media milling method is employed to prepare azithromycin nanocrystals, from which azithromycin nanocrystals tablets are made. The quality of the tablets is evaluated referring to Chinese Pharmacopoeia, the dissolution rates are measured by paddle method, and the content and related substances are determined by HPLC. The stabilities are investigated by impact factors test, short-time test and retention samples test. The results show that the quality of the homemade tablets meets the requirements of tablets in Appendix of volume Ⅱ of Chinese Pharmacopoeia (2010), and their dissolution rates increases significantly compared with the reference preparations. Impact factors test indicates that the homemade tablets are stable in the condition of high temperature or strong light but sensitive to environmental humidity. Short-time test and retention samples test results show that the homemade tablets are stable within 6 months, so they should be sealed and stored in a cool dry place.