In order to improve the stability of train at high speed running state and enhance the ride comfort, this paper carried out the simulation and analysis of the semi-active suspension control system by using the minimum variance control algorithm, and presents the design scheme of the semi-active suspension control system of high-speed trains based on the minimum variance control. The simulation platform was built by Matlab-Simulink. The simulation results show a considerable improvement of lateral vibration, as compared with the traditional passive suspension mode.