Electrochemical oxidation of secondary effluent of oxytetracycline wastewater is investigated using Ti/RuO₂-IrO₂ plate as anode and graphite plate as cathode, respectively. The results show that when current density is 0.10 A/cm2, electrodes span is 2 cm, concentration of electrolyte (Na₂SO₄) is 0.3 mol/L and the initial pH of the wastewater isn't adjusted, the 264.32 mg/L of COD concentration of the inffluent electrochemical is reduced below 120.00 mg/L after being oxidized for 60 min. The COD removal rate is over 60%. The electrochemical oxidation degradation process of COD is approximate complied with the first-order kinetics equation: ln(c₀/c_t) = 0.012 9t -0.001 7 (R2=0.997 5).