To analyze the effects of axle load and interlayer bonding on the load stress of concrete pavement, the contact elements to reflect the state of interlayer bonding are applied within rigid base and concrete pavement, and three dimensional numerical model of concrete pavement under the vehicle loads is set up. Then the model is used to research the effects of interlayer bonding on the load stress of rigid base and concrete pavement under standard axle load and those of axle load on loading stress of concrete pavement. The results including: 1) With increasing interlayer bonding, the tensile stress at the bottom of concrete pavement decreases, while the tensile stress at the bottom of rigid base slightly increases. 2) With axle load increasing, the tensile stress at the bottom of concrete pavement increases. And with increasing interlaying bonding, increasing velocity of the tensile stress at the bottom of concrete pavement greatly decreases. 3) Under the conditions of overloading, interlayer bonding is more advantageous for concrete pavement with load stress and temperature stress.