The inclusion compound of indomethacin and SEB7-β-CD were prepared by saturated solution method, grinding method and freeze-dried method. The inclusion compound was identified by differential scanning calorimetric method. The contents of indometacin and inclusion rate were determined by the ultraviolet spectrometry(UV). Encapsulation efficiency of the SBE-β-CD inclusion compound prepared by grinding method can reach 61.0%. And the preparation of inclusion compound by grinding method makes drug molecules overcome the steric hindrance of the SBE-β-CD and enter the cavity of host molecules, so as to improve the inclusion rate.