The composition of azithromycin wastewater is very complex. It has the characteristics of high pH value, deep color, high COD, low BOD, and low decomposability. The ferric-carbon micro-electrolysis is used to dispose azithromycin wastewater, and the various influence factors are studied. Results show that the optimal conditions are as follows:the reaction temperature is 25℃, m(Fe)/m(C) is 3∶1,the initial pH is 4, the amount of Fe is 0.45g/L, and the reaction time is 2h. Finally up to 53.21% COD could be removed under the above best technological conditions.