Acetyl derivatives of imidazolidin were prepared by the reaction of acetyl imidazolidin with aspirin and indomethacin, non-steroidal anti-inflammatory drugs, respectively. Then their effect on the learning and memory function of mice is studied. According to mosaic theory to modify the chemcial constitution, the target compound was synthesized by halogenation and condensation reaction. After that, the praxiological changes of each group of mice are analyzedl by adopting the means of morris water maze. Two new compounds are obtained:2-(1-acetyl-2-oxoimidazol-idine-3-carbonyl)phenyl acetate (the target compound A)and 1-acetyl-3-(2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetyl)imidazolidin-2-one(the target compound B), with yield of 20.7% and 30.5%. The target compound A could shorten the time for swimming the whole process and decrease the times of mistakes compared with the model group in the Morris Water Maze tests. The process is stable, safe and free from pollution in mild condition.The target compound A is beneficial to increase the learning and memory capacities of mice.