To prepare gastric mucoadhesive pellets of domperidone and study the release behaviour and adhesive in vitro, carbopol, hydroxypropyl cellulose(HPC) and PVP are used as the main adhesive materials, 30% NaCl(mass ratio) solution is used to be a wetting agent of soft wood, and extrusion-spheronization method is used to prepare pellets. Taking adhesion in vitro and sustained release behavior of the pellets as indicators, through orthogonal design, we optimized and verified the best prescription.The mass ratio of carbopol, hydroxypropyl cellulose(HPC) and PVP is 80∶80∶15.In vitro test data show that domperidone adhesion sustained-release pellets have good adhesion and release effect.The formulation and process developed in the study is convenient, repeatable and suitable for mass production.