Non-premixed and premixed non-catalytic partial oxidation process were studied.Premixed combustor was used to non-catalytic partial oxidation process,with H₂/CO ratio close to 2in outlet gas.Effects of O₂/CH_4on composition of outlet gas was studied in the constant temperature.The premixed combustion module of CHEMKIN4.0was used to simulate experimental process,whose results were consistent with the experimental results.Process conditions optimazied to prepare methanol were as follows:Reaction temperature 900℃,O₂/CH_4ratio 0.50,pressure 100kPa,H₂/CO ratio close to 2.00.