MnO₂/MWCNTs-modified graphite electrode was prepared by cyclic voltammetry (CV), and its catalysis for oxygen reduction reaction in neutral and alkaline medium was investigated respectively by the electrochemical technique. It is shown that the higher electrocatalysis of MnO₂/MWCNTs for ORR is exhibited when compared to the MWCNTs-modified electrode and MnO₂-modified graphite electrode; electrocatalysis of MnO₂/MWCNTs for ORR is increased when the content of OH-in solution enhanced, and higher stable catalysis for ORR is also exhibited by MnO₂/MWCNTs.