The domino effect of linkage between knowledge innovation and economic growth mode conversion presents this trend:on the one hand, the knowledge innovation promotes the course of economic growth mode conversion, and makes the knowledge factor play a more and more important role in the process of economic growth; on the other hand, the economic growth mode conversion prinks up the momentum of the knowledge innovation. This paper analyzes the phenomena based on the practical data of Nantong city, Jiangsu province.