The automatic stereo warehouse system is a storage system with multi-storey warehouse, by which the automation access and integrated automation management are realized in the computer's direct control and management. The emerging, bypass automatic stereo warehouse has gained more and more application in rapid access. The stacker's working time directly affects the efficiency of the warehouse. To improve the bypass automatic warehouse efficiency and analyze the stacker route, an integrated optimization model considering the export selection and the path picking is established. The model aims to the picking task cycle and develops the population's generating method of genetic algorithm, then solves the optimization model. The last section in this stage is the initial point of the next optimization stage, using the nearest neighbor method to find the optimal export location. Simulation and practical application show that the model and the algorithm are feasible and effective.