：Aiming at the problem that antibiotics residue can not be utilized in a short time，In this work, the combustion kinetics and synergistic effects of penicillin residue and its mixture with coal (denoted as 5~30% for the mass fraction bacterial residue) were investigated by using thermogravimetric analysis. The experiments were performed via a thermogravimetric simultaneous thermal analyzer at five heating rates (10, 15, 20, 25 and 30 ℃/min) with a changing temperature ranged from room temperature to 900℃. The combustion process of blends was systematically investigated, and the activation energy of the combustion process of the blends was calculated by Flynn-Wall-Ozawa(FWO) and Vyazovkin(V), the kinetic mechanism function was solved by the integral master graph method. The results showed that co-combustion of the blends mainly consisted of two processes which were the volatile matter combustion of bacterial residue and the combustion of coal fixed carbon, synergistic effects existed for all the blends. With the increase of the bacterial residue blending ratio, the activation energy of the blends present an increasing trend. While the bacterial residue blending ratio was 10%, the average activation energy of the blends was the lowest and the synergistic effects was the strongest, the activation energy calculated by the two methods were 139.63 kJ/mol (FWO) and 141.67 kJ/mol (V), respectively. The mechanism function was further solved by integrating master graph method, and the mechanism function of the first stage of combustion reaction was [-ln(1-α)]4, the reaction mechanism was “random nucleation and subsequent growth”, the mechanism function of the second stage was α2, and the reaction mechanism was “one-dimensional diffusion”. The results provide a preliminary theoretical basis for the co-operation disposal of penicillin residue and coal in cement kiln. The experimental results can effectively understand the combustion characteristics of antibiotics residue and coal, and provide theoretical reference for the co-processing of antibiotics residue.