In order to study the stability of cefuroxime axetil acetone solution. Using high-performance liquid chromatography, a single-factor experiment was used to study the law of the content of cefuroxime axetil in the solution over time under different conditions such as the initial solution pH, temperature, oxidant species and so on. The chemical reaction kinetics method was used to establish the degradation reaction kinetics models of cefuroxime axetil under different conditions. The model parameters were obtained by regression and the half-life (t_1/2) was predicted. The results show that the degradation of cefuroxime axetil acetone solution under the above conditions is in line with the first-order reaction kinetics. When pH value is less than 9.54, cefuroxime axetil acetone solution is basically stable. When the pH value is greater than 9.54, the chemical stability of cefuroxime axetil acetone solution becomes worse, the degradation rate increases rapidly with the pH value, and the color of the solution becomes darker with the pH value increasing. The chemical stability of cefuroxime axetil acetone solution decreases with the increase of temperature. Provide data support for production process, crystallization process design, storage and application.