| 周晓辉,常亚南,何晓亮,张晋弘.Ⅱ型胶原蛋白的结构、功能及其最新研究进展[J].河北科技大学学报,2017,38(2):202-208 |
| Ⅱ型胶原蛋白的结构、功能及其最新研究进展 |
| Structure, function and latest research development of collagen of type Ⅱ |
| 投稿时间：2016-09-23 修订日期：2016-12-16 |
| DOI：10.7535/hbkd.2017yx02016 |
| 中文关键词: 蛋白质工程 Ⅱ型胶原蛋白 透明软骨 组织工程 基因重组 |
| 英文关键词: protein engineering collagen of type Ⅱ hyaline cartilage tissue engineering gene recombination |
| 基金项目:河北省“百人计划”资助项目(E2012100005)；教育部留学回国人员科研启动基金(4720131792) |
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| 中文摘要: |
| Ⅱ型胶原蛋白是动物体内透明软骨的主要成分，具有良好的生物相容性、可降解性、可促进细胞生长和再分化等生物学特性，可作为人体组织工程材料，也可应用于食品、日化、包装等领域。利用基因工程技术生产重组Ⅱ型胶原蛋白是该领域的研究热点。综述了Ⅱ型胶原蛋白的结构、功能及应用，阐述了基因工程技术生产重组Ⅱ型胶原蛋白的最新研究进展，对未来羟化胶原蛋白在大肠杆菌中的大规模生产进行了展望，以期为Ⅱ型胶原蛋白的进一步开发和同行研究提供指导和帮助。 |
| 英文摘要: |
| Collagen of type Ⅱ is the major component of hyaline cartilage in animals. Based on its biocompatibility, biodegradability and many other biological properties, for example promoting cell growth and differentiation, collagen of type Ⅱ has been widely applied in various fields, such as tissue engineering material, food, cosmetic, packaging, etc.. In recent years, using genetic engineering to produce recombinant collagen of type Ⅱ is popular. The structure, function and application of collagen of type Ⅱ are described, the latest research progress for producing recombinant collagen of type Ⅱ by genetic engineering is put forward, and the large-scale production of hydroxylated collagen in E.coli in the future is previewed, which would be helpful for the further development and study of collagen of type Ⅱ. |
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