Medical needle injection is a commonly used treatment method in modern medical treatment. However, the pain caused by skin irritation in the injection process brings out severe discomfort. In this regard, scholars at home and abroad have conducted extensive studies to reduce the pain caused by needle injection. Insects, including mosquitoes, cicadas and bees, have the function of easily piercing the skin of animals and plants, which have been regarded as bionic prototypes for development of painless injection needles. Starting from the mechanism of pain generation when the injection needle pierces the skin, the measurement methods of pain perception and the bionic mechanism of bionic prototype were summarized; the bionic mechanism of low resistance suture needle was mainly analyzed, and research status of the microneedle array material selection and preparation was introduced; the application prospect of painless injection needle in low resistance suture needle was analyzed. Meanwhile, it was pointed out that the future research should focus on the application of high-precision 3D printing technology and laser micro processing technology in the preparation of bionic painless injection needles, so as to obtain the preparation technology with precise processing accuracy.
国家自然科学基金（51205107）; 河北省高等学校青年拔尖人才资助项目（BJ2017011）; 河北省自然科学基金（E2019208306）