抗菌肽的抗菌机制及其在医药中的应用前景
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河北省高等学校科学技术研究项目(ZD2018080); 京津冀三地联合攻关项目(19YFSLQY00100)


Antimicrobial mechanism and application prospects in medicine of antimicrobial peptides
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    摘要:

    随着抗生素副作用的日益凸显,以及其被批准数量的逐年下降,研发功能相似且不易产生耐药性的其他活性物质迫在眉睫。抗菌肽具有广谱抗菌性、热稳定性,作用机理独特,既能起到体内抗病菌感染、促进癌细胞凋亡的作用,还可作为抗病毒化疗剂和医疗器械的抗菌材料。系统综述了抗菌肽的抗菌机制,及其在医药领域抑制抗耐药菌的产生、抗癌以及抗病毒感染的作用,阐明了抗菌肽存在的稳定性、溶血性及毒性等问题,并对其发展前景进行了展望。指出今后可在以下方面对抗菌肽展开深入研究:1)结合体内抑菌机制进行研究,推动抗菌肽的开发应用;2)通过替换、修饰氨基酸残基,合成杂合肽,优化抗菌肽结构,提高其活性,降低毒副作用并预防耐药性的产生;3)利用抗菌肽传递系统或抗菌肽与绿色天然提取物联合作用,提高抗菌活性和生物利用度。

    Abstract:

    As the side effects of antibiotics are becoming increasingly prominent and the number of approvals is declining year by year, it is urgent to develop other active substances that are similar in functions and not easy to develop drug resistance. Antimicrobial peptides (AMPs) have broad-spectrum antibacterial activities, thermal stability and unique mechanism of action. They can not only play the role of anti-bacterial infection in vivo and promote apoptosis of cancer cells, but also be used as chemotherapeutic agents against virus and antibacterial materials for hospital settings. In this paper, developments related to antimicrobial mechanisms and activities of antimicrobial peptides against drug-resistant bacteria, anticancer and antiviral infection in the field of medicine are systematically reviewed. The problems of stability, hemolytic and toxicity of antimicrobial peptides are elucidated and the development prospects of AMPs in medicine are provided. Further research on AMPs can be carried out in the following aspects in the future. 1) Antibacterial mechanism in vivo are studied to promote the development and application of antimicrobial peptides;2)Structures of AMPs are optimized by replacing and modifying amino acid residues and hybrid peptides are synthesized to improve their activities, reduce side effects and prevent drug resistance; 3)Application of delivery systems for AMPs or combination of AMPs with green natural extracts is investigated to improve their antibacterial activity and bioavailability.

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贾艳丽,仇 燕.抗菌肽的抗菌机制及其在医药中的应用前景[J].河北科技大学学报,2021,42(1):67-74

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  • 收稿日期:2020-08-10
  • 最后修改日期:2020-10-28
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  • 在线发布日期: 2020-12-18
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